Clomiphene citrate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

一种非甾体类化合物，广泛使用的生育剂，可抑制下丘脑的雌激素受体。

A non-steroidal, a widely used fertility agent that inhibits estrogen receptor in the hypothalamus; shows antibacterial activity by inhibiting undecaprenyl diphosphate synthase, an enzyme that catalyzes the synthesis of a polyisoprenoid essential for both peptidoglycan and wall teichoic acid (WTA) synthesis.Other Indication Approved.

Cell Viability Assay Cell Line:PC3 human prostate cancer cells Concentration:50 μM Incubation Time:1 min, 2 min, 5 min, 10 min, 15 min, 20 min, 30 min Result:Reduced cell viability by 10-50% for 2-15 min in a time-dependent manner.

Animal Model:Female ICR miceDosage:25 mg/kg, 50mg/kg, 100mg/kg Administration:Intraperitoneal injection (i.p.) Result:Resulted in a decrease in the number of ovulated oocytes and a significant increase in hyperploidy at 100 mg/kg.Animal Model:letrozole(HY-14248)-induced PCOS rats Dosage:1 mg/kg Administration:Oral Result:Demonstrated a statistically raised NRF-2 gene expression.Up-regulated expression of NF-κB.Showed a reversal of the memory defect.Down-regulated of acetylcholine esterase expression.

Clomifene citrate

Endocrinology/Hormones

Estrogen Receptor/ERR

ER

Other Indications

Other Disease

50-41-9

598.0831

C32H36ClNO8

>98% (HPLC)

10 mM in DMSO

CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O

Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

(-20℃)

With Ice Pack

≥ 2 years